Matthew Perry’s official cause of death confirmed: ‘Acute effects of ketamine’

Friends star Matthew Perry’s official cause of death has been confirmed by the LA County Medical Examiner’s Office.

Matthew Perry. Picture: Kevin Winter/Getty

Matthew Perry’s official cause of death has been confirmed.

TheFriends star died of “acute effects of ketamine,” according to the LA County Medical Examiner’s Office.

The autopsy report also lists drowning, coronary artery disease and buprenorphine effects as other conditions that contributed to his death.

The late actor was found dead at his home in the Pacific Palisades neighbourhood of Los Angeles on Saturday from an apparent drowning. He was 54.

First responders were called to the house for a cardiac arrest after Perry was discovered unresponsive in a jacuzzi by his assistant, sources told TMZ at the time.

Per the outlet, no illegal drugs were found at the scene.

Matthew Perry’s sad cause of death has now been publicly revealed. Picture: Getty

However, law enforcement sources later told TMZ that multiple prescription drugs were found, including anti-depressants, anti-anxiety drugs and a COPD drug.

COPD, or chronic obstructive pulmonary disease, refers to the diseases that cause airflow blockage and breathing-related problems, according to the CDC.

The disease can also lead to chronic bronchitis and emphysema. Perry previously admitted to being a smoker during his life.

The “Fools Rush In” star had also struggled with drug addiction over the years.

Matthew Perry's eery final Instagram post, shared days before he would die in the same spot.

In a 2002 interview with the New York Times, the actor revealed that his fear of dying led him to get clean.

“I didn’t get sober because I felt like it,” Perry said. “I got sober because I was worried I was going to die the next day.”

The Whole Nine Yards star was last seen six days before his death while out with a friend in Los Angeles. He was photographed looking casual and relaxed outside of the Apple Pan hamburger spot.

Perry, seen here with Friends co-star Matt LeBlanc in 2004, had battled drug and alcohol addiction for decades before his death. Picture: Carlo Allegri/Getty

In his final Instagram post, which was uploaded October 23, Perry shared an eerie photo of himself lounging in a jacuzzi.

“Oh, so warm water swirling around makes you feel good? I’m Mattman,” he wrote in the caption.

Perry’s loved ones and former co-stars have been mourning the loss on social media following his passing.

Meanwhile, an insider told Page Six that his Friends castmates — Jennifer Aniston, Courteney Cox, David Schwimmer, Lisa Kudrow and Matt LeBlanc — are in shock from the “devastating” news.

Perry’s Friends castmates like Courteney Cox (pictured) are mourning the loss of their “brother.” Picture: Getty

“The cast is reeling from the loss of their brother, because that’s what Matty was — their brother,” an industry source told us Sunday.

The late actor’s family also released a statement regarding his “tragic” death.

“We are heartbroken by the tragic loss of our beloved son and brother. Matthew brought so much joy to the world, both as an actor and a friend,” they shared with People Sunday.

“You all meant so much to him and we appreciate the tremendous outpouring of love.”

This story originally appeared on Page Six and is republished here with permission.