Medical experts have backed criticism from business that Victorian Premier Daniel Andrews' lockdown exit plan is a blunt attempt to eliminate COVID-19 which will cripple the state's economy and have urged the Prime Minister to broker talks to revisit the targets.

Melbourne's leading medical, business and cultural figures are appealing to the PM and backing calls for the modelling to be released to allow independent experts to review the assumptions and road map, amid widespread anger the targets are too high and the response is too blunt.