Victorian Premier Daniel Andrews has assured residents that the government has "learned lessons" from the state's previous hotel quarantine failure.
"We know that there are many lessons that have to be learned in relation to hotel quarantine, and we have learned those lessons, from Victoria and experiences in Adelaide, and experiences in Sydney," Mr Andrews said on Monday.
"Breaches of hotel quarantine are not unique to Victoria, we have to be focused on the best system, the stronger system, to keep Victorians a safe to protect this precious thing that we have built."
The premier's assurances come as Victoria is set to resume accepting international arrivals from December 7, with 160 residents set to return and quarantine in Victoria each day.
The hotel quarantine system has been restructured with a new administrative team dedicated to keeping the system running safely.
"This will be done as safely as possible, but we all have to acknowledge that there is no quarantine system that can be built with zero risk," Mr Andrews said.
"There will always be some residual risk, some would say that it is inevitable that there will be outbreaks, that there will be cases, the key point is to make sure that we have the stronger system in place to lockdown any outbreak, to shut that down, without having to shut down the suburbs, or metropolitan Melbourne, or the entire state.
"We are confident we will be able to do that because of the planning, the learnings, and the experiences here at around Australia."
The ADF will also be supporting police in ensuring COVID protocols are followed.
All staff working in the quarantine system will work at one site only, in a bid to reduce the risk of the virus spreading.
Mr Andrews also noted all staff will be exclusively employed or contracted for the quarantine system, meaning no private security contactors or people working second jobs.