McKeon was part of the mixed 4x100m medley relay team that won gold, giving her a 19th career Commonwealth Games medal (with 13 gold) - the first time an athlete has ever racked up that much hardware.
The record previously belonged to shooter Phillip Adams, who won 18 medals across five different Games before his retirement in 2002.
Elsewhere, Ariarne Titmus claimed her sixth Commonwealth Games gold medal in the 800m freestyle while Cody Simpson also competed in the 100m butterfly final alongside national champion Matt Temple, who finished in a dead heat for silver.
Updates
McKeon makes Comm Games history
James Matthey
Australia's mixed 4x100m medley relay team of Kaylee McKeown, Zac Stubblety-Cook, Matthew Temple and Emma McKeon combined to claim yet another gold medal.
The win gives McKeon her 13th Commonwealth Games gold medal and historic 19th medal overall. The 28-year-old has now won more medals than any athlete in Commonwealth Games history, surpassing shooter Phillip Adams – who boasts 18 medals across five Games.
McKeown started proceedings before Temple and Stubblety-Cook took care of the middle legs. McKeon then anchored the race to perfection as Australia won its 17th medal of the day in the pool.
The Aussies were all smiles.
Teenage Aussie star stuns McKeon
James Matthey
Australian teenager Mollie O'Callaghan has emerged as Australia's next swimming sensation, stunning Emma McKeon to win gold in the women's 100m freestyle final.
Shayna Jack claimed silver ahead of McKeon, whose third-placed finish gave her an 18th career Commonwealth Games medal.
At just 18, O'Callaghan blitzed the field with an incredible personal best of 52.63 seconds.
"I'm really happy. And I'm happy to do it with these amazing girls. Especially Emma. She is an absolute idol," O'Callaghan said.
"It is really nice to race alongside her at this time.
"And especially Shayna Jack too, coming back from stuff, so I'm very happy."
McKeon won gold in the 100m freestyle at the Tokyo Olympics but just one year later, she was outgunned by her compatriots.
O'Callaghan put swimming fans on notice at the recent World Championships in Budapest with a swag of medals, and she's shown the hype is real with a stunning effort to topple Australia's queen of the pool.
It's her first individual gold medal at a major international meet and comes after the teen gave Ariarne Titmus an almighty scare in the 200m freestyle final.
Mollie O Callaghan (middle) is a superstar on the rise.
Jack, too, was sensational, coming back from a doping ban and broken hand to pip McKeon at the death for silver.
McKeon was all class after the race as she paid tribute to her Dolphins teammates.
"It is incredible. We get to push each other, year in and year out. And it ups the standard every time," she told Channel 7's Cate Campbell on the pooldeck. "You forged the pathway for us to do that, so we're pretty lucky.
"After last year, I needed to keep pushing. And I know all over the world there will be young ones coming through and I have these two back home to race all the time.
"I'm still hungry as ever … I'm just so stoked to be here and be in the 100m with those girls."
Titmus terminates the competition
James Matthey
Ariarne "The Terminator" Titmus has added another gold medal to her personal haul, winning the 800m freestyle final in a green and gold clean sweep of the podium.
The Olympic silver medallist streaked away to touch the wall several body lengths ahead of fellow Australian Kiah Melverton, while Lani Pallister was third.
Titmus now has six Commonwealth Games gold medals as a result of her stunning swim – a new personal best time of 8:13.59 that also set a fresh Games record.
Disaster strikes for Australian ballers
James Matthey
England broke Australian hearts by snatching the gold medal out of our hands in the 3×3 basketball.
The home side dropped a two-pointer in overtime to claim top spot.
Australia fires around the grounds
James Matthey
Para-swimmer Col Pearse made history by winning gold in the first ever men's 100m butterfly S10, ahead of fellow Australian Alex Anthony Saffy.
Also in the pool, Jasmine Greenwood added another gold to the medal tally in the women's 200m individual medley SM10.
In gymnastics James Bacueti won bronze in the men's vault and Kate McDonald beat countrywoman Georgia Godwin to gold in the women's beam.
Australia's 3×3 wheelchair basketball team won gold by defeating Canada 11-9 and weightlifter Eileen Cikamatana took the top prize in the women's 87kg class by lifting a Commonwealth Games record 110kg in the snatch and 129kg in the clean and jerk.
'I don't like it': Aussie wins gold after taking a risk
James Matthey
Nina Kennedy backed up her bronze medal at the recent Athletics World Championships by claiming pole vault gold in Birmingham.
The 25-year-old made things harder for herself than she needed to. After successful vaults at 4.35m and 4.45m, a clearance of 4.50m would have been enough to seal victory. However, Kennedy bypassed that height as well as an attempt at 4.55m, instead opting to go the extra mile at 4.60m.
It was a call that "befuddled" Channel 7 athletics commentator David Culbert, who questioned why Kennedy was taking a risk by going for a more difficult height than what was required.
"I don't like it," Culbert said.
His fears appeared well founded when Kennedy baulked in her first attempt at 4.60m, pulling out of her run-up before taking off. It was second time lucky, though, as she cleared the bar, leaving Culbert to breathe a sigh of relief.
"Why? That's the question," he said. "It was unnecessary pressure. She didn't need to make it that tough."
The risk paid off for Nina Kennedy
After securing first place, Kennedy went for a Commonwealth Games record at 4.76m but it wasn't to be.
Speaking to Channel 7 after her golden effort, Kennedy said the win was "more of a relief" than elation.
"It (the gold medal) was definitely mine to lose so I kept my cool and I'm so happy with the gold. Wow," she said.
"The Worlds (World Championships) is our pinnacle so to come to the Commonwealth Games, this was to make my friends and my family and my support team proud. This was definitely for them, I'm so happy I did it."
The British star finished ahead of Australian silver medallist Sam Williamson.
Temple wins silver, Cody 5th in final
James Matthey
Australian Matthew Temple finished in a dead heat for silver in the 100m butterfly final, sharing second place with England's James Guy.
Joshua Liendo Edwards of Canada claimed the gold medal while Cody Simpson finished fifth.
More medals for Australia
James Matthey
There were more medals for Australia in the women's 200m butterfly final.
Elizabeth Dekkers claimed gold ahead of England's Laura Stephens, while fellow Aussie Brianna Throssell won bronze.
Aussie misses gold by barest of margins
James Matthey
Aussie Bradley Woodward claimed a silver medal in the 200m backstroke, finishing just 0.01 seconds behind the winner.
England's Brodie Paul Williams won gold by the barest of margins, while Pieter Coetze of South Africa won bronze. Australian veteran Mitch Larkin was fourth.
"Obviously a bit disappointed with that on the touch. But for me, you can see yourself on the big screen coming in, I turned in the last 50 and saw us all pretty close," Woodward said.
"And I thought if I have to win this, I have to go. And it was hurting a bit and then trying to get on the finish. Just missed out."
Commentating for Channel 7, Ian Thorpe suggested an unusually slow reaction off the blocks may have cost Woodward.
"We noticed a delay right there at the start, that we saw from Bradley Woodward," Thorpe said. "It was odd … it was quite a fast start in terms of when the gun was fired, for the athletes to get underway."
