In a section dealing with international affairs, Joe Biden signalled his commitment to multilateral action, implicitly rejecting the "America first" attitude of his predecessor.
"No one nation can deal with all the crises of our time," he said, citing the pandemic as one of several examples.
"There's no wall high enough to keep any virus out. And our own vaccine supply, as it grows to meet our needs – and we're meeting them – will become an arsenal for vaccines for other countries. Just as America is an arsenal for democracy around the world."
Another example was climate change.
"It's not our fight alone, it's a global fight," said Mr Biden.
"That's why I rejoined the Paris Climate Accord, because if we (alone) do everything perfectly, it's not going to matter.
"My intent was to make sure that there was a consensus. If we act to save the planet, we can create millions of jobs and economic growth and opportunity for everyone around the world."
Not for the first time in this speech, he explicitly mentioned China's role as a rising power in Asia.
"We welcome the competition. We're not looking for conflict. But I made absolutely clear that we will defend America's interests across the board," he said.
Mr Biden said he had told Chinese President Xi Jinping the US would "stand up to unfair trade practices" and the "theft" of intellectual property, and maintain a military presence in the region.
"America will not back away from our commitments to our alliances, our commitment to human rights and to fundamental freedoms," he said.
"No responsible American president could remain silent while fundamental human rights are being violated."