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11-year-old Leukaemia patient first cured with CAR T-cell in Australia

An 11-year-old boy has had his genes reprogrammed and become the first person in Australia to be cured of cancer using a breakthrough treatment.

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An 11-year-old boy’s five-year-battle with a rare leukaemia has come to a happy end after he was cured thanks to a new form of treatment being offered in Australia.

Kamm Denieger became the first person in NSW to receive chimeric antigen receptor T-cell therapy (also known as CAR T-cell) at the Kids’ Cancer Centre at Randwick, which started offering it in August last year to treat aggressive acute lymphoblastic leukaemia, like the type Kamm had.

“I feel quite special,” Kamm told 7 News.

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Kamm Denieger was declared cancer-free a month after treatment. Picture: 7 NEWS
Kamm Denieger was declared cancer-free a month after treatment. Picture: 7 NEWS

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“Thank you, I can’t thank you enough for what you’ve done for me,” he said.

During the young boy’s battle, doctors tried chemotherapy as well as transplanting bone marrow from his younger sister, Erin, but it failed to keep the cancer at bay.

So, as part of his treatment, doctors took Kamm’s blood and used genetic reprogramming to adapt the immune cells, so when they were reintroduced to his bloodstream, they began attacking and eliminating the cancerous cells.

One month later he was declared cancer-free.

Research is ongoing into the potential of CAR T-cell treatment for other cancers.
Research is ongoing into the potential of CAR T-cell treatment for other cancers.

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Prior to the introduction of CAR T-cell therapy within the Sydney Children’s Hospital network, patients would have to travel to the United States for treatment.

CAR T-cell therapy targets the white blood cells that bolster our immune systems and help the body respond to pathogens.

“This is the most breakthrough therapy in the treatment of aggressive acute lymphoblastic leukaemia that we’ve seen in decades,” Kids Cancer Centre head assistant professor Tracey O’Brien said at the announcement that the centre would offer the treatment.

CAR T-cell has currently proven to be effective in treating cancers like acute lymphoblastic leukaemia and large B-cell lymphoma, but researchers are working to determine if it can be used to treat solid ones like breast and prostate cancer.

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Original URL: https://www.news.com.au/technology/science/human-body/11yearold-leukaemia-patient-first-cured-with-car-tcell-in-australia/news-story/3aa6e2c67e2984e0c888654b60c07d8f