The win reclaims the number one spot on the ATP rankings, where he will sit ahead of Carlos Alcaraz at No. 2 and Tsitsipas at No. 3.
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While the world was hoping for a close match, it was rather one-sided despite Djokovic's troublesome hamstring as he never looked worried on his own serve.
Even when he lost his first serve of the third set, he broke straight back and took the match to a tie-break.
Djokovic dropped just one set at Melbourne Park this season in his second round match to Frenchman Enzo Couacaud.
But the Serbian superstar, who moves back equal with Rafael Nadal for the most grand slam title wins in history at 22, was unstoppable racing through the tournament.
Despite the relative ease of the win, Djokovic was emotional after the match, openly sobbing into his towel.
"He's so mentally tough on the court, almost invincible," Jim Courier said in commentary. "But we're seeing a very human side of Novak this evening."
The reaction was swift for the Serbian star's remarkable comeback a year after he was deported after his visa was cancelled by then-Immigration Minister Alex Hawke over his decision to remain unvaccinated.
Despite the relative ease he dominated the tournament with, he said it was "one of the most challenging tournaments I have ever played in my life."
"Considering the circumstances not playing last year, coming back this year, I want to thank all the people that made me feel welcome, made me feel comfortable to be in Melbourne, to be in Australia," Djokovic said.
"There is a reason why I've played my best tennis throughout my career in Australia and on this court in front of legendary Rod Laver. Thank you so much for being present tonight, sir.
"I tried to pinch myself and really live through these moments and it's a long journey.
"I just have to say this because only the team and the family knows what we've been through in the last four or five weeks and this probably is the I would say the biggest victory in my life considering the circumstances."
Tennis Australia chair Jayne Hrdlicka announced: "The King of Melbourne Park is back".
But Tsitsipas had the most telling words, declaring Djokovic was "he's the greatest that has ever held a tennis racquet for sure."
"It speaks for yourself what you have achieved so far," Tsitsipas said.
"It's all in the numbers. Congratulations. Not only to yourself but to having, like, such supportive family.
"You know, I think it's very similar the way we grew up around tennis, so it's been an unbelievable journey for you so I admire what you have done for our sport. I think you make me a better player when I am on the court, so thank you.
"I've had the privilege to play a lot of difficult, high- intensity matches but I would like to say one more time Novak brings the best out in me they've been working my whole life for. He's the one of the greatest in our sport and I think - he's the greatest that has ever held a tennis racquet for sure.
"I haven't done this but I'd like to thank you for pushing our sport so far. I think it deserves a player like you that pushes everyone, every single player, every single individual that's involved in the sport to the max."
Djokovic thanked Tsitsipas for his words and "being so kind and respectful".
Updates
Novak Djokovic is the 2023 Australian Open champion, extending his record to a 10th title at Melbourne Park and equalling Rafael Nadal at the top of the men's grand slam tally list with his 22nd major.
Djokovic has had a ruthless tournament, dropping just one set despite a troublesome hamstring injury.
While Djokovic's 10 titles is now four beyond the next best of Aussie Roy Emerson and Roger Federer at six each, we now have to assess Djokovic on a different scale.
As Serbia's only champion at the Australian Open, he has made Serbia just the third nation to win more than 10 Australian Opens, and just the second in the Open era.
Australia dominated the Amateur Era with 44 titles when it was mostly Aussies in the draw and have won six mens titles since for a total of 50 titles, while Djokovic is hot on the heels of the US' 14 Open era titles to go with its four Amateur Era wins for 18 titles overall.
Stefanos Tsitsipas broke Novak Djokovic to start the third set… but immediately gave it back and now the third set is back on serve.
The Greek star needs the set to stay alive, while Djokovic is this set away from his 10th Australian Open title.
Novak Djokovic is now just a set away from his record-extending 10th grand slam title.
Stefanos Tsitsipas was much better in the second set, fighting back admirably but after bring the tiebreak back to 4-4 after falling 4-1 behind, he lost the last three points to give Djokovic the 6-4 7-6 lead.
And if history is any gauge, there's not a lot of hope for Tsitsipas.
Any belief that this would be all one way traffic has been dispelled in the second set.
Stefanos Tsitsipas is fighting back after a scappy start where the Serbian superstar broke early to take the first.
But the second has been on serve with both men getting a chance to break.
Djokovic is being made to run around a lot more than he was in the first as Tsitsipas found his rhythm.
It got to a point Djokovic fell over, although it was not due to his hamstring and he quickly recovered.
However, he wasn't happy.
Djokovic has been jawing with his coach Goran Ivanisevic and it's clear he's being tested by the young Greek.
The commentators said it was "concerning" for the 21-time grand slam champ.
Losing the first set is the worst possible news for Stefanos Tsitsipas as he looks for his maiden grand slam win.
Djokovic broke in the fourth game of the first set and didn't look back, sealing the first set 6-3.
Tsitsipas needed a lightning start but the Serbian star was the one who made the most of his opportunities, racing to win the first set.
It's ominous for Tsitsipas as in 92 matches, Djokovic has never lost at the Australian Open after winning the first set.
Novak Djokovic has been putting plenty of pressure on Stefanos Tsitsipas, claiming the first break to make it 3-1 in the first set.
On his first service game, Tsitsipas saved two break points, but on the second, a double fault gave the Serbian the brilliant early start.
Djokovic is all over Tsitsipas' second serve, probably helps when it's your 33rd grand slam final, compared to the Greek's second.
Novak Djokovic's dad Srdjan is not in the player's box for the Australian Open final.
Srdjan landed in hot water when he posed with fans after Novak's quarterfinal win over Andrey Rublev, seemingly unwittingly taking photos with pro-war protesters who had Russian flags with Vladimir Putin's face on it.
Tennis Australia had said he was free to make his own call as to whether he'd be there.
Whether he's meant to do it or not, Novak Djokovic has reignited the speculation over whether his troublesome hamstring is as bad as he has made it out to be.
Djokovic has had his left hamstring heavily strapped throughout the tournament when matches have begun, even limping at points.
Perhaps hours on court in matches and constant treatment is finally working for the world No. 5 as ahead of the final against Stefanos Tsitsipas, Djokovic stepped out on court with no strapping.
Asked about how much his hamstring would hamper Djokovic, Lleyton Hewitt said of watching Novak in action against Alex de Minaur that the Serbian didn't seem too hampered by the injury.
"He looked incredible, moving across the baseline (against de Minaur)," Hewitt said.
"He looked so sharp out there. It is the open stance backhand we've talked about in commentary in his matches. I think he's been trying to protect it as much as possible.
"He only goes to that shot really sliding out there when he needs it, on a big point. It will be interesting early tonight how often he goes to that. Tsitsipas has the weighted shot.
"A lot heavier ball than a lot of the other players throughout the tournament so far, which could be a worry for Novak."
Earlier in the tournament, Jim Courier slammed talk Djokovic may be faking the injury.
"There's been a lot of chatter on the grounds here, and I think elsewhere out in the social media stratosphere, where all things are true of course, that Novak isn't injured," he said.
"The evidence I would present, if I was presenting the case on his behalf, is simply he's not moving to the ball and doing that motion as much as he normally would.
"He is making adjustments at a major – a grand slam tournament – that you just would never see him do unless he was concerned about a problem.
"It doesn't hold up to the logic test that he would be faking this. Makes no sense.
"Because by doing different motions he could risk injuring himself in a different way."
Whether it's feeling better, or he testing it out, it's going to do nothing to stop the talk it was all just a ploy rather than a legitimate injury concern as most of the world can't believe he could be on the cusp of a 10th Australian Open win with a bum hammy.
When he arrived on court, Djokovic had minimal tape, with just some structural tape on his leg for the match.
Czech pair Barbora Krejcikova and Katerina Siniakova are without a doubt women's doubles' most dominant pair right now.
The pair were dominant, finishing Japanese 10th seeds Shuko Aoyama and Ena Shibahara 6-4 6-3 for the title.
The duo combine for a seventh Australian Open title and are just a second US Open title away from two career Grand Slams as they defended their Australian Open title.
The pair have won four of the last five grand slam, missing just the French Open in 2022, a tournament they won in 2018 and 2021 – only because Krejcikova tested positive to Covid just before the start of the doubles tournament.
With Krejcikova just 27 and Siniakova 26, there's a chance they could go up among the greats of tennis, despite still being a long way off Martina Navratilova's grand slam doubles title record of 31.
Novak Djokovic's father Srdjan has been given the go ahead to attend the Australian Open final on Sunday night.
Tennis Australia boss Craig Tiley said the decision was in the hands of the Serbian after he opted to remain at home for Friday's semi-final.
It comes in the wake of Srdjan being seen with pro-Russian demonstrators outside Rod Laver Arena on Wednesday night.
The Serbian tennis star’s father posed for a photo with a man who wore symbols that supported Russia’s invasion of Ukraine, and was also holding a Russian flag featuring Vladimir Putin’s face.
On Sunday morning, Mr Tiley said Mr Djokovic had not breached the event policy when he engaged with the demonstrators.
“There are individuals that come on site with a purposeful intent to disrupt the enjoyment of other fans,” Mr Tiley told Nine.
“Those individuals will be removed. Certainly Novak’s dad was not in that position of doing that.
“It was one of those situations where he was around people that were enjoying it and one or two individuals in that crowd that shouldn’t have been here on site.”
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