Why some people with Parkinson’s develop shocking reactions to medications

Queensland researchers have used a novel technique to discover how medications for Parkinson’s disease can cause some patients to develop addictive behaviours like problem gambling, binge eating, hypersexuality and excessive shopping.

QUEENSLAND researchers have used a virtual casino to discover how medications given to Parkinson’s disease sufferers can cause one in six to develop shocking, addictive behaviours such as gambling, binge eating and excessive shopping.

Medicines that increase dopamine levels in the brain are the cornerstone of treatment for symptoms of Parkinson’s disease, the neurodegenerative disorder that damages nerve cells which produce dopamine in the deep structures of the brain.

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QIMR Berghofer Medical Research Institute lead researcher and St Andrews Hospital

neuropsychiatrist Dr Phil Mosley said while dopamine replacement therapy was effective for most people diagnosed with Parkinson’s disease, about one in six people treated with the medication developed impulse-control behaviours, such as gambling.

“We found people who developed these addictive behaviours differed in the way their brain

structure interacted with dopamine-containing medication, which gave rise to the impulsive

behaviour,” Dr Mosley said.

Another impressive finding by Queensland scientists

“None of these people had a history of addictive behaviours before diagnosis and only developed them after they began treatment with dopamine-replacement medications. There is currently no way of predicting which individuals are at risk of these terrible side-effects,” he said.

More than 80,000 Australians are living with Parkinson’s disease, with most people diagnosed after the age of 65.

Dr Mosley said the study recruited 57 people with Parkinson’s disease from St Andrews War

Memorial Hospital in Brisbane, in collaboration with neurologist Professor Peter Silburn.

“We used an advanced method of brain imaging, called diffusion MRI, to reconstruct the connections between different regions of the brain, akin to developing an individualised brain “wiring” diagram for each person in the study,” Dr Mosley said.

“We asked our participants to gamble in a virtual casino, which gave us a readout of impulsive and risk-taking behaviour in real time. By combining data from brain imaging, behaviour in the virtual casino and the effect of dopamine replacement medication, we were able to identify people who were susceptible to impulse-control behaviours. More broadly, we found a clear link between the strength of the connections in the brain, within circuits that we think are crucial for making decisions and suppressing impulses, and impulsive behaviour, even in people without clinically-significant impulse-control behaviours,” he said.

Dr Mosley said the study findings indicated that brain imaging and computer-based testing could be used in the future to determine which individuals were at risk.

“We could offer targeted education to at-risk individuals, or adapt their treatment regimen to

minimise the potential harms from these therapies,” he said.

The research findings have been published today in the journal Brain.