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Adelaide researchers using prawn shells to quell back surgery pain

SITTING at the Christmas lunch table, struggling to take the shell off another prawn after three beers, it’s unlikely you are wondering what it is about the shell that makes it so annoying to remove.

Yes, it’s wet and makes your fingers sting after a while from all the sharp edges, but take a moment, if you can, to ponder what makes it so tough, but so bendy at the same time.

It’s chitosan (to save you the Googling time) and it’s what gives the shell flexibility and strength.

Now, Adelaide researchers are working to find out if the same properties could help those suffering with one of the most common kinds of severe back pain — the type suffered by almost half of the patients who undergo surgery for herniated discs.

Some describe it as pins and needles.

Others as electric shocks running from the back down the legs and into the feet.

Still more describe it as the worst pain they have ever experienced.

Herniated disc with leg pain is the most common indication for back surgery in western society and around 10 per cent of those patients will need surgery.

Prof Sarah Vreugd and Prof Peter-John Wormald are some of the team behind new research that uses a protein from prawn shells to combat back pain. Picture: Bianca De Marchi
Prof Sarah Vreugd and Prof Peter-John Wormald are some of the team behind new research that uses a protein from prawn shells to combat back pain. Picture: Bianca De Marchi

But scarring and adhesions mean, instead of experiencing an easing of pain, up to 40 per cent of patients suffer significant post-operative chronic pain known as failed back syndrome.

Despite this, there are currently no therapies available to these patients to help relieve their pain.

Led by Professor Peter-John Wormald, a research team at Woodville’s Basil Hetzel Institute has discovered a gel — made from the chitosan found in prawn shells currently used to treat nasal inflammation following surgery — can also be used to prevent scarring following routine back surgery.

Now armed with the support of a grant from The Hospital Research Foundation, this innovative gel will soon be available to patients through a clinical trial.

Researcher associate professor Sarah Vreugde says the gel prevents scarring mainly because it forms a barrier between different sides of the wound that, when in contact, can ‘fuse’ and form adhesions.

“More than 800,000 spine surgeries occur annually globally and provide relief in some cases,’’ Vreugde says.

But pain from adhesions often follows.

“The key is prevention of adhesions from forming,’’ Vreugde says

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More than 800,000 spine surgeries occur annually globally and provide relief in some cases.

.

“However, there are no approaches or products on the market that can do this. Once adhesions are present and cause severe pain, patients receive standard pain medication but, if not sufficient, they may need a second operation just to remove the adhesions.”

It’s hoped the gel - which also has a medication usually used to treat some forms of anaemia added to it - will improve wound healing and prevent the adhesions from forming, greatly improving the lives of those post-surgery.

Prof Wormald hopes even those with shellfish allergy will be able to use the product.

“The gel is highly chemically modified so we don’t think that using the gel in a patient who has shell allergies would be a problem,’’ he says.

“However, just to be extra safe, we have not included anyone with shell fish allergy in any of our trials to date.”

And it’s not just back surgery patients who stand to benefit from the research.

Already used successfully after sinus surgery, there is potential for the gel to be used in abdominal surgery.

“Currently we are investigating the use of this combination product for the prevention of adhesions after bowel and gynaecological surgery as adhesions after such surgery is common and cause major complications including bowel obstruction.”

Original URL: https://www.adelaidenow.com.au/smart-sa/adelaide-researchers-using-prawn-shells-to-ease-pain-caused-by-back-surgeries/news-story/07676f44a0c5c03f5529577d70e082cd